Discipline of Virology

Publications

PUBLICATIONS

2021

Msomi N, Lessells RJ, Mlisana K, de Oliveira T : Africa: tackle HIV and COVID-19 together Nature.2021 Dec; 600   

https://www.nature.com/articles/d41586-021-03546-8

Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, Doolabh D, Pillay S, San EJ, Msomi N, Mlisana K. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature. 2021 Apr;592(7854):438-43.

https://www.nature.com/articles/s41586-021-03402-9

Tegally H, Wilkinson E, Lessells RJ, Giandhari J, Pillay S, Msomi N, Mlisana K, Bhiman JN, von Gottberg A, Walaza S, Fonseca V. Sixteen novel lineages of SARS-CoV-2 in South Africa. Nature Medicine. 2021 Mar;27(3):440-6.

https://www.nature.com/articles/s41591-021-01255-3

Castillo-Mancilla JR, Edwards J, Jaysingh B, Moosa M, Zhao Y, Ofotokun I, Johnson BJ, Lee M, Pillay S, Pillay M et al: Tenofovir Diphosphate in Dried Blood Spots is Associated with Virologic Failure and Resistance to first-line therapy in South Africa: a case-control cohort study. Journal of the International AIDS Society 2021, In Press

Ellapen MT, Ellapen TJ, Paul Y. The growth patterns of the medical technology profession in South Africa. Afr.J.Lab.Med. 2021;10(1):1-5.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111615/

Soobramoney C, Parboosing R: siRNAs and viruses: The good, the bad and the way forward. Curr Mol Pharmacol 2021. 

https://www.ncbi.nlm.nih.gov/pubmed/33881977

Chimukangara B, Lessells RJ, Sartorius B, Gounder L, Manyana S, Pillay M, Singh L, Giandhari J, Govender K, Samuel R et al: HIV-1 drug resistance in adults and adolescents on protease inhibitor-based antiretroviral treatment in KwaZulu-Natal Province, South Africa. J Glob Antimicrob Resist 2021. 

https://www.ncbi.nlm.nih.gov/pubmed/34785393

Govender K, Msomi N, Moodley P, Parboosing R: Cytomegalovirus pneumonia of infants in Africa: a narrative literature review. Future Microbiol 2021. 

https://www.ncbi.nlm.nih.gov/pubmed/34812046

Fagnant-Sperati CS, Ren Y, Zhou NA, Komen E, Mwangi B, Hassan J, Chepkurui A, Nzunza R, Nyangao J, van Zyl WB et al: Validation of the bag-mediated filtration system for environmental surveillance of poliovirus in Nairobi, Kenya. J Appl Microbiol 2021, 130(3):971-981.

 https://www.ncbi.nlm.nih.gov/pubmed/32743931

Venugopala KN, Deb PK, Pillay M, Chopra D, Chandrashekharappa S, Morsy MA, Aldhubiab BE, Attimarad M, Nair AB, Sreeharsha N et al: 4-Aryl-1,4-Dihydropyridines as Potential Enoyl-Acyl Carrier Protein Reductase Inhibitors: Antitubercular Activity and Molecular Docking Study. Curr Top Med Chem 2021, 21(4):295-306. 

https://www.ncbi.nlm.nih.gov/pubmed/33138763

Maduray K, Parboosing R: Metal Nanoparticles: a Promising Treatment for Viral and Arboviral Infections. Biol Trace Elem Res 2021, 199(8):3159-3176. 

https://www.ncbi.nlm.nih.gov/pubmed/33029761

Ziningi Nobuhle J, Tivani PM-T, Raveen P: Self-Sampling Interventions for Sexually Transmitted Infections in Women: A Scoping Review Protocol. Research Square 2021. 

https://doi.org/10.21203/rs.3.rs-64831/v1

Reynolds Z, McCluskey SM, Moosa MYS, Gilbert RF, Pillay S, Aturinda I, Ard KL, Muyindike W, Musinguzi N, Masette G et al: Who’s slipping through the cracks? A comprehensive individual, clinical and health system characterization of people with virological failure on first-line HIV treatment in Uganda and South Africa. HIV Med 2021. 

https://www.ncbi.nlm.nih.gov/pubmed/34755438

Siedner MJ, Moosa MS, McCluskey S, Gilbert RF, Pillay S, Aturinda I, Ard K, Muyindike W, Musinguzi N, Masette G et al: Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa : An Unblinded Randomized Controlled Trial. Ann Intern Med 2021. 

https://www.ncbi.nlm.nih.gov/pubmed/34698502

Chimukangara B, Lessells RJ, Singh L, Grigalionyte I, Yende-Zuma N, Adams R, Dawood H, Dlamini L, Buthelezi S, Chetty S et al: Acquired HIV drug resistance and virologic monitoring in a HIV hyper-endemic setting in KwaZulu-Natal Province, South Africa. AIDS Res Ther 2021, 18(1):74. 

https://www.ncbi.nlm.nih.gov/pubmed/34656129

Bardon AR, Dorward J, Sookrajh Y, Sayed F, Quame-Amaglo J, Pillay C, Feutz E, Ngobese H, Simoni JM, Sharma M et al: Simplifying TREAtment and Monitoring for HIV (STREAM HIV): protocol for a randomised controlled trial of point-of-care urine tenofovir and viral load testing to improve HIV outcomes. BMJ Open 2021, 11(10):e050116. 

https://www.ncbi.nlm.nih.gov/pubmed/34610939

Dorward J, Sookrajh Y, Ngobese H, Lessells R, Sayed F, Bulo E, Moodley P, Samsunder N, Lewis L, Tonkin-Crine S et al: Protocol for a randomised feasibility study of Point-Of-care HIV viral load testing to Enhance Re-suppression in South Africa: the POwER study. BMJ Open 2021, 11(2):e045373. 

https://www.ncbi.nlm.nih.gov/pubmed/33593788

Hird TR, Partap U, Moodley P, Pirie FJ, Esterhuizen TM, O’Leary B, McCarthy MI, Young EH, Sandhu MS, Motala AA: HIV infection and anaemia do not affect HbA1c for the detection of diabetes in black South Africans: Evidence from the Durban Diabetes Study. Diabet Med 2021, 38(11):e14605. 

https://www.ncbi.nlm.nih.gov/pubmed/34028093

 

2020

Nelson KN, Gandhi NR, Mathema B, Lopman BA, Brust JCM, Auld SC, Ismail N, Omar SV, Brown TS, Allana S et al: Modeling Missing Cases and Transmission Links in Networks of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa. Am J Epidemiol 2020, 189(7):735-745. 

https://www.ncbi.nlm.nih.gov/pubmed/32242216

Msomi N, Mlisana K, de Oliveira T, Network for Genomic Surveillance in South Africa writing g: A genomics network established to respond rapidly to public health threats in South Africa. Lancet Microbe 2020, 1(6):e229-e230. 

https://www.ncbi.nlm.nih.gov/pubmed/32838349

Msomi N, Naidoo K, Yende-Zuma N, Padayatchi N, Govender K, Singh JA, Abdool-Karim S, Abdool-Karim Q, Mlisana K: High incidence and persistence of hepatitis B virus infection in individuals receiving HIV care in KwaZulu-Natal, South Africa. BMC Infect Dis 2020, 20(1):847. 

https://www.ncbi.nlm.nih.gov/pubmed/33198649

Khan A, Hans L, Hsiao NY: Comparison of Alere q whole blood viral load with DBS and plasma viral load in the classification of HIV virological failure. PLoS One 2020, 15(5):e0232345. 

https://www.ncbi.nlm.nih.gov/pubmed/32469947

Dookie N, Padayatchi N, Lessells RJ, Naicker CL, Chotoo S, Naidoo K: Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded Drug-Susceptibility Testing. Clin Infect Dis 2020, 71(11):2981-2985. 

https://www.ncbi.nlm.nih.gov/pubmed/32384148

Chimukangara B, Giandhari J, Lessells R, Yende-Zuma N, Sartorius B, Samuel R, Khanyile KS, Stray-Pedersen B, Moodley P, Metzner KJ et al: Impact of pretreatment low-abundance HIV-1 drug-resistant variants on virological failure among HIV-1/TB-co-infected individuals. J Antimicrob Chemother 2020, 75(11):3319-3326. 

https://www.ncbi.nlm.nih.gov/pubmed/32772079

Dorward J, Drain PK, Osman F, Sookrajh Y, Pillay M, Moodley P, Garrett N: Short Communication: Early Antiretroviral Therapy Is Associated with Better Viral Suppression and Less HIV Drug Resistance After Implementation of Universal Treatment in South Africa. AIDS Res Hum Retroviruses 2020, 36(4):297-299. 

https://www.ncbi.nlm.nih.gov/pubmed/31663368

Mitha M, Pillay M, Moodley JY, Balakrishna Y, Abbai N, Bhagwan S, Dangor Z, Bhigjee AI: Laboratory diagnosis of tuberculous meningitis in human immunodeficiency virus-seropositive patients: Correlation with the uniform case definition. S Afr J Infect Dis 2020, 35(1):135. 

https://www.ncbi.nlm.nih.gov/pubmed/34485474

 

 

Venugopala KN, Tratrat C, Pillay M, Chandrashekharappa S, Al-Attraqchi OHA, Aldhubiab BE, Attimarad M, Alwassil OI, Nair AB, Sreeharsha N et al: In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis. Drug Des Devel Ther 2020, 14:1027-1039.

 https://www.ncbi.nlm.nih.gov/pubmed/32214795

Venugopala KN, Uppar V, Chandrashekharappa S, Abdallah HH, Pillay M, Deb PK, Morsy MA, Aldhubiab BE, Attimarad M, Nair AB et al: Cytotoxicity and Antimycobacterial Properties of Pyrrolo[1,2-a]quinoline Derivatives: Molecular Target Identification and Molecular Docking Studies. Antibiotics (Basel) 2020, 9(5). 

https://www.ncbi.nlm.nih.gov/pubmed/32392709

Venugopala KN, Kandeel M, Pillay M, Deb PK, Abdallah HH, Mahomoodally MF, Chopra D: Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4H-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular Dynamics. Antibiotics (Basel) 2020, 9(9). 

https://www.ncbi.nlm.nih.gov/pubmed/32878018

Brijkumar J, Johnson BA, Zhao Y, Edwards J, Moodley P, Pathan K, Pillay S, Castro KG, Sunpath H, Kuritzkes DR et al: A packaged intervention to improve viral load monitoring within a deeply rural health district of South Africa. BMC Infect Dis 2020, 20(1):836. 

https://www.ncbi.nlm.nih.gov/pubmed/33176715

Rautenberg TA, George G, Bwana MB, Moosa MS, Pillay S, McCluskey SM, Aturinda I, Ard K, Muyindike W, Moodley P et al: Comparative analyses of published cost effectiveness models highlight critical considerations which are useful to inform development of new models. J Med Econ 2020, 23(3):221-227. 

https://www.ncbi.nlm.nih.gov/pubmed/31835974

Nelson KN, Jenness SM, Mathema B, Lopman BA, Auld SC, Shah NS, Brust JCM, Ismail N, Omar SV, Brown TS et al: Social Mixing and Clinical Features Linked With Transmission in a Network of Extensively Drug-resistant Tuberculosis Cases in KwaZulu-Natal, South Africa. Clin Infect Dis 2020, 70(11):2396-2402. 

https://www.ncbi.nlm.nih.gov/pubmed/31342067

Drain PK, Dorward J, Violette LR, Quame-Amaglo J, Thomas KK, Samsunder N, Ngobese H, Mlisana K, Moodley P, Donnell D et al: Point-of-care HIV viral load testing combined with task shifting to improve treatment outcomes (STREAM): findings from an open-label, non-inferiority, randomised controlled trial. Lancet HIV 2020, 7(4):e229-e237. 

https://www.ncbi.nlm.nih.gov/pubmed/32105625

Smith JP, Gandhi NR, Shah NS, Mlisana K, Moodley P, Johnson BA, Allana S, Campbell A, Nelson KN, Master I et al: The Impact of Concurrent Antiretroviral Therapy and MDR-TB Treatment on Adverse Events. J Acquir Immune Defic Syndr 2020, 83(1):47-55.

 https://www.ncbi.nlm.nih.gov/pubmed/31809360

 

 

Naicker CL, Mansoor LE, Dawood H, Naidoo K, Singo D, Matten D, Williamson C, Abdool Karim Q: Importance of early identification of PrEP breakthrough infections in a generalized HIV epidemic: a case report from a PrEP demonstration project in South Africa. BMC Infect Dis 2020, 20(1):532. 

https://www.ncbi.nlm.nih.gov/pubmed/32698772

Zhou NA, Fagnant-Sperati CS, Komen E, Mwangi B, Mukubi J, Nyangao J, Hassan J, Chepkurui A, Maina C, van Zyl WB et al: Feasibility of the Bag-Mediated Filtration System for Environmental Surveillance of Poliovirus in Kenya. Food Environ Virol 2020, 12(1):35-47. 

https://www.ncbi.nlm.nih.gov/pubmed/31679104

2019

Swe Swe-Han K, Pillay M, Pillay M: Amikacin-resistant Acinetobacter species mediated by the aphA6 gene associated with clinical outcome at an academic complex hospital in KwaZulu-Natal Province, South Africa. S Afr Med J 2019, 110(1):49-54. 

https://www.ncbi.nlm.nih.gov/pubmed/31865943

Peterson ML, Gandhi NR, Clennon J, Nelson KN, Morris N, Ismail N, Allana S, Campbell A, Brust JCM, Auld SC et al: Extensively drug-resistant tuberculosis ‘hotspots’ and sociodemographic associations in Durban, South Africa. Int J Tuberc Lung Dis 2019, 23(6):720-727. 

https://www.ncbi.nlm.nih.gov/pubmed/31315705

Smith S, Govender K, Moodley P, La Russa P, Kuhn L, Archary M: Impact of Shifts to Birth Testing on Early Infant Diagnosis Program Outcomes in KwaZulu-Natal, South Africa. Pediatr Infect Dis J 2019, 38(7):e138-e142. 

https://www.ncbi.nlm.nih.gov/pubmed/31192977

Motaze NV, Manamela J, Smit S, Rabie H, Harper K, duPlessis N, Reubenson G, Coetzee M, Ballot D, Moore D et al: Congenital Rubella Syndrome Surveillance in South Africa Using a Sentinel Site Approach: A Cross-sectional Study. Clin Infect Dis 2019, 68(10):1658-1664. 

https://www.ncbi.nlm.nih.gov/pubmed/30203002

Simeon K, Sharma M, Dorward J, Naidoo J, Dlamini N, Moodley P, Samsunder N, Barnabas RV, Garrett N, Drain PK: Comparative cost analysis of point-of-care versus laboratory-based testing to initiate and monitor HIV treatment in South Africa. PLoS One 2019, 14(10):e0223669. 

https://www.ncbi.nlm.nih.gov/pubmed/31618220

Stephens F, Gandhi NR, Brust JCM, Mlisana K, Moodley P, Allana S, Campbell A, Shah S: Treatment Adherence Among Persons Receiving Concurrent Multidrug-Resistant Tuberculosis and HIV Treatment in KwaZulu-Natal, South Africa. J Acquir Immune Defic Syndr 2019, 82(2):124-130. 

https://www.ncbi.nlm.nih.gov/pubmed/31513073

Chimukangara B, Lessells RJ, Rhee SY, Giandhari J, Kharsany ABM, Naidoo K, Lewis L, Cawood C, Khanyile D, Ayalew KA et al: Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000-2016: A Pooled Sequence Analysis. EClinicalMedicine 2019, 9:26-34. 

https://www.ncbi.nlm.nih.gov/pubmed/31143879

Msomi N, Ndlovu K, Giandhari J, Wilkinson E, Parboosing R, Zungu S, Mlisana K: High rate of occult hepatitis B virus infection in hemodialysis units of KwaZulu-Natal, South Africa. J Med Virol 2019, 91(10):1797-1803. 

https://www.ncbi.nlm.nih.gov/pubmed/31180137